Collagen Sheets

Collograft L is a sterile collagen lyophilized in sheet form and is crafted from bovine source. Collograft L’s use has been widely accepted for biological wound dressing especially for burns. It is highly effective for patients including those with HIV and Hepatitis infection.2. MECHANISM OF ACTION:Collagen is an extra cellular matrix protein playing a major role in connective tissue. It is the most abundant protein in humans and performs multiple functions. In bovine source is present in the largest concentration of collagen. Collagen as a bio-material and its role in wound management is a well documented subject.INTENDED USE/INDICATION: Ulcers-Chronic, Pressure (Shallow), Venous/Vascular & Diabetic 2nd degree & Superficial burns Skin donor sites Surgical wounds, Traumatic wounds (abrasions, skin tears etc) Instructions for use: Prepare-Prepare the wound bed to make it free of exudates and devitalized tissue. Wait for any bleeding to stop before applying Collograft L sheet. Apply-Measure the wound and select the appropriately sized sheet of Collograft L. Cut the sheet to size and position it to cover the wound surface, extending slightly beyond the margins. If multiple sheets are required, overlap edges. Anchor-As required, anchor Collograft L sheet using the physician’s preferred fixation method (eg. Tissue sealant, bolsters, dissolvable clips, sutures, or staples). Rehydrate-Gently rehydrate Collograft L sheet with sterile saline. Dress-Apply a non-adherent primary wound dressing over the Collograft L sheet. The primary dressing is usually changed on day 3-5 to avoid product disruption. Cover-Select appropriate secondary dressing based on type of wound and amount of exudates. Collograft L sheet may be used under compression bandages. Reasses-The wound should be free of infection and necrosis. Carefully remove any remaining loose product around the wound edge as needed. If necessary, reapply Collograft L over previously absorbed application.Reapply- Reapply Collograft L sheet typically between 3-5 days or as needed, repeating the above steps as appropriate. If a gel forms on the wound surface, do not attempt to forcibly remove. Gently rinse the wound surface, leaving the extracellular matrix (ECM) gel intact.

Colloskin is a sterile collagen in sheet form and is crafted from bovine source. Colloskin's use has been widely accepted for biological wound dressing especially for burns. It is highly effective for patients including those with HIV and hepatitis infections.

Indications :

• Ideal for Non-infective 2nd degree burns,
• Superficial & deep dermal burns
• For 3rd Degree burns as a temporary cover
• Traumatic loss of skin cover.
• Temperary wound cover in major open fracture wound
• Skin donor sites

Directions for Use :

• Throughly clean and denude areas to dliminate external contamination.
• Throughly debride infected wound.
• Take out the collagen sheet from the preserving medium and squeeze it to remove the excess preserving medium adhered to the colloskin.
• Take a trough and fill it with sterile saline water and rinse the colloskin throughly 2-3 times to remove the alcohol (preserving medium).
• Apply the sheet firmly on the wound and remove the air bubbles trapped if any for effective adhesion.
• For best results avoid second dressing over colloskin.
• As epitheliasation occurs, colloskin sheet peels off.
• Colloskin promotes healthy granulation in deep wounds for early grafting.
• Repeated dressing not required unless colloskin is rejected due to underlying pus or complication.
• For skin donor sites, colloskin must be applied after achieving satisfactory hemostasis.
• For chronic skin ulcers, 2 to 3 applications of coloskin or more in 2-3 day intervals must be repeated after thorough cleaning each time, thus enhancing healing.
• In cases where the adhered collokin has to be removed from the wound, a saline, moist pad can be applied over colloskin for a few minutes to facilitate easy removal.

Advantages :
Widely accepted for biological wound dressing especially for burns

• Single application on clean wounds.
• Prevents infection
• Instant pain relief
• Quick and firm adherence
• Allows skin to breath
• Preserves local heat
• Stimulates healthy granulation

Sizes available : 5cms x 5cms, 10cms x 10cms, 10cms x 25cms, 15 x30 cms and as per customer requirement.

Colloskin-M Sterile Wet Collagen Sheet in Meshed Form . Usage On Exuding/ Infected Burns and Wounds for Easy Drainage of the Fluid. Colloskin-M use has been widely accepted for biological wound dressing especially for burns. It is highly effective for patients including those with HIV and hepatitis infections.

Indications :

• Ideal for Non-infective 2nd degree burns,
• Superficial & deep dermal burns
• For 3rd Degree burns as a temporary cover
• Traumatic loss of skin cover.
• Temperary wound cover in major open fracture wound
• Skin donor sites

Directions

• Throughly clean and denude areas to eliminate external contamination.
• Throughly debride infected wound.
• Take out the collagen sheet from the preserving medium and squeeze it to remove the excess preserving medium adhered to the Colloskin –M.
• Take a trough and fill it with sterile saline water and rinse the Colloskin –M throughly 2-3 times to remove the alcohol (preserving medium).
• Apply the sheet firmly on the wound and remove the air bubbles trapped if any for effective adhesion.
• For best results avoid second dressing over Colloskin –M.
• As epitheliasation occurs, Colloskin –M sheet peels off.
• Colloskin –M promotes healthy granulation in deep wounds for early grafting.
• Repeated dressing not required unless Colloskin –M is rejected due to underlying pus or complication.
• For skin donor sites, Colloskin –M must be applied after achieving satisfactory hemostasis.
• For chronic skin ulcers, 2 to 3 applications of Colloskin-M or more in 2-3 day intervals must be repeated after thorough cleaning each time, thus enhancing healing.
• In cases where the adhered Colloskin-M has to be removed from the wound, a saline, moist pad can be applied over Colloskin –M for a few minutes to facilitate easy removal.

Advantages :
Widely accepted for biological wound dressing especially for burns

• Single application on clean wounds.
• Prevents infection
• Instant pain relief
• Quick and firm adherence
• Allows skin to breath
• Preserves local heat
• Stimulates healthy granulation

Sizes available : 5 x 5 cms, 10 x 10cms, 10 x 25cms, 15 x 30 cms

Sterile Dry collagen sheet advantages :

• Ready to use transparent self adhesive and dry membrane that offers complete flexibility.
• Accelerates healing rate minimises dressing.
• Reduces scarring by depositing oriented and organised fibres
• Regulates the amount of collagenase expressed by keratinocytes.
• Reduces wound treatment costs by 40%

Sizes : 5x5 cms, 10 x 10 cms, 10 x 25 cms, 15 x 30 cms

Applications :

• Partial and full thickness wounds
• Pressure ulcers
• Venous Ulcers
• Chronic Vascular ulcer
• Diabetic ulcers
• Trauma wounds (abrasions, lacerations, second degree burns, skin tears)
• Surgical wounds (Donor sites, Grafts, Post moh's surgery, post laser surgery, paediatric and wound dehiscence)

Precautions

Collograft should be avoided for the patients Hypersensitive to collagen

Collograft-B is a dry collagen sheet, with non-adherant, Absorbant baking.It is used for effective management of moderate to heavy draining wounds.

Dry collagen sheet with Non adherant absorbant backing

• Purified Type-1 Collagen with Medical Grade PU Foam backing
• Flexible and tacky.
• Facilitates healing and hemostatic
• PU foam layer absorbs the exudes and keeps the wound free from contamination.
• Collagen is absorbed by the tissue in 6 to 10 days

Applications : All type of surface wounds Moderate to heavily draining wounds

Sizes Available : 5 x 5 cms, 10 x 10cms, 10 x 20 cms, 15 x 30 cms

Diacoll is a collagen Gentamicin sheet in the form of a sponge/transparent flim containing collagen and gentamicin sulphate. The collagen gentamicin implant is composed of highly purified type – I collagen obtained from bovine Tendon, which acts as a vehicle for the antimicrobial gentamicin. The collagen is derived from specifically controlled and certified animals and is highly purified to avoid any antiginicity. Gentamicin sulphate is a wide spectrum antibiotic that provides highly effective topical treatment in primary and secondary bacterial infections of the skin. Diacoll^TM is produced using the latest triple helix collagen technique to provide an optimum degree of flexibility and rigidity combined with the most predictable resorptive process.

Mechanism of Action :
Diacoll^TM comprises of a collagen foam incoproated with gentamicin sulphate. When applied on teh wound the collagen foam acts as a vehicle for the antimicrobial gentamicin. Collagen is absorbed slowly by the tissue in 6 to 10 days after is application. The purpose of the implant is to provide a high concentration of local gentamicin at the site of implantation. The Diacoll^TM comes prepacked and sterile and is intended for single use only.

Indications :

• Diabetic foot ulcers.
• Orthopedic surgery.
• Treatment of osteomylitis and soft tissue infections.
• Abdominal wound infections.

Directions for use :

• In all cases standard established sterile surgical procedure must be observed.
• Diacoll^TM should be cut to the desired size to ideally extend 2-3mm beyond the edge of teh defect (s).
• The sheet once wet with blood tends to adapt extremely well to the bone/tissue walls.

Applications of Diacoll^TM implant on first day.

• Prepare the wound bed : Change and dispose of the old dressing in a safe, careful and appropriate manner.
• Accomplish appropriate wound debriment.
  
  • Irrigate the wound gently and carefully with sterile saline water until wound is free of debris, necrotic slough etc.
  • Gently blot wound edges and peri-wound margins dry.
• Apply Diacoll^TM
  • Take the appropriate size of the Diacoll^TM cut open the sterile pouch.
  • Cut the Diacoll^TM According to the shape of the wound and apply it to the wound surface.
  • When applied to the wound surface it tends of adapt extremely well to the bone / tissue walls.
• Wound care dressing : The area may be covered with gauze dressing if desired.

Precautions & Comments :

• Wounds may appear larger during first several days of treatment due to reduction of edema.
• An increase in drainage may be seen in the first several days of treatement.
• Treatment of the underlying conditons (Venous or arterial flow, external pressure as well as nturitional support should proceed concurrently with the use of Diacoll^TM.
• Avoid patient hypersensitive to collagen, Gentamicin.
• A transient burning sensation may be experienced by a small percentage of patients.

How supplied : Diacoll^TM implant is supplied in the following sizesin a gamma sterilized pouch.

Sizes Available : 5cm x 5cm, 10cm x 10cm, 15cm x 30cm, 15cm x 65cm